Luxury Vacation Rentals in South Carolina

Never book a bad vacation home again. Every Wander comes with hotel-grade amenities, inspiring views, pristine cleaning and 24/7 concierge service.

We found 598 vacation rentals – enter your dates for availability.

Top-rated vacation rentals in South Carolina

HH2611: 2611 High Hammock

4 bedrooms•4.5 baths

•

New

~$210 less than other sites

IOP Life - 27 22nd Avenue

6 bedrooms•6 baths

•

~$315 less than other sites

Luxury

Beach Please - 10 32nd Ave

5 bedrooms•4.5 baths

•

~$280 less than other sites

Luxury

The Rosewood Retreat - 2605 Palm Blvd

7 bedrooms•8 baths

•

New

~$370 less than other sites

Oceanside Villas 211C - Villa Solea - 1400 Ocean Blvd Unit 211C

2 bedrooms•2 baths

•

~$80 less than other sites

Luxury

Surfside IOP - 2904 Skinner Blvd

4 bedrooms•4 baths

•

~$290 less than other sites

Dunescape Condos 103 - Palms Postcard

3 bedrooms•3 baths

•

~$150 less than other sites

Palmetto Beach Retreat - 405 Palm Blvd

3 bedrooms•2.5 baths

•

~$130 less than other sites

Welcome to South Carolina

Find your coastal escape with Wander’s collection of luxury vacation rentals in South Carolina. From oceanfront retreats on Hilton Head Island to serene Lowcountry escapes in Murrells Inlet and family-friendly homes in Garden City Beach, every stay pairs privacy with polished design.

Expect hotel-grade standards across the board: spotless housekeeping, 24/7 concierge, ultra fast WiFi for work days, private pools and gyms for downtime, and chef-ready kitchens. Each home is thoughtfully outfitted with smart features and plush linens so you can unpack once and relax.

Destinations in South Carolina

Hilton Head Island

Murrells Inlet

Garden City Beach

Available soon in South Carolina

DP2981: 2981 Deer Point

5 bedrooms•3.5 baths

•

New

~$240 less than other sites

5 Junket

6 bedrooms•6.5 baths

•

New

~$525 less than other sites

BW3131: 3131 Baywood Drive

6 bedrooms•5.5 baths

•

New

~$315 less than other sites

37 Sea Lane

7 bedrooms•6 baths

•

New

~$280 less than other sites

3 Talon Court

4 bedrooms•4 baths

•

New

~$155 less than other sites

Brand New Sea Pines Home located on the 15th Hole of Atlantic Dunes with pool

6 bedrooms•6 baths

•

~$435 less than other sites

24 Cartgate

5 bedrooms•4.5 baths

•

New

~$270 less than other sites

5 Osprey

6 bedrooms•4.5 baths

•

New

~$285 less than other sites

Featured vacation rentals in South Carolina

Luxury

Ultra Luxe Home, Pool & Spa, Screened Porch, 5 Min Walk to Beach

6 bedrooms•7 baths

•

~$755 less than other sites

CM3302: 3302 Cameron Blvd

6 bedrooms•5.5 baths

•

New

~$335 less than other sites

Luxury

BHP18: 18 Blue Heron Pond Road

5 bedrooms•4.5 baths

•

New

~$380 less than other sites

AV19-21: 19 21st Avenue

6 bedrooms•5 baths

•

New

~$335 less than other sites

Luxury

9 Juniper

8 bedrooms•7.5 baths

•

New

~$530 less than other sites

12 Sea Front Lane

7 bedrooms•8 baths

•

~$490 less than other sites

CM3008: 3008 Cameron Blvd

7 bedrooms•7 baths

•

New

~$280 less than other sites

Luxury

Beautiful New Beach Home with Private Pool, Spa & Stunning Beach Views

7 bedrooms•7.5 baths

•

~$710 less than other sites

Highlights in South Carolina

Discover a state where historic cities, sun-drenched coastlines, and classic Southern charm create an unforgettable and diverse travel experience.

Charleston's Historic District

Myrtle Beach Boardwalk and Promenade

Hilton Head Island

Fort Sumter National Monument

Congaree National Park

South Carolina State House

Caesars Head State Park

Magnolia Plantation and Gardens

IT'S A VACATION HOME, BUT BETTER

The Wander difference

Wander is different because we combine the quality of a luxury hotel with the comfort of a private vacation home. Your best trip ever is just a few clicks away.

Only the best homes

We’ll never not look like the pictures. Every Wander is beautiful and expertly operated, so you can leave any stress at the door.

Hotel-grade amenities

We’ll never leave you with nothing to do. From ultra fast WiFi to gyms and pools, our homes make it easy to blend work and play.

24/7 concierge service

We’ll never leave you hanging. Our chat-based Concierge is always available to help – from trip questions to special requests.

Inspiring and stunning views

We’ll never leave you uninspired. Every Wander has stunning views to refresh and inspire your soul. Adventure awaits.

Meticulous cleaning

We’ll never have you check in to a dirty house. Our cleaning teams are meticulous, and there are no chores at checkout.

Safety and security

We’ll never pass you off to a stranger. Every Wander location meets our industry-leading safety standards to give you peace of mind.

All homes in South Carolina

HH2611: 2611 High Hammock

4 bedrooms•4.5 baths

•

New

~$210 less than other sites

IOP Life - 27 22nd Avenue

6 bedrooms•6 baths

•

~$315 less than other sites

Luxury

Beach Please - 10 32nd Ave

5 bedrooms•4.5 baths

•

~$280 less than other sites

Luxury

The Rosewood Retreat - 2605 Palm Blvd

7 bedrooms•8 baths

•

New

~$370 less than other sites

Oceanside Villas 211C - Villa Solea - 1400 Ocean Blvd Unit 211C

2 bedrooms•2 baths

•

~$80 less than other sites

Luxury

Surfside IOP - 2904 Skinner Blvd

4 bedrooms•4 baths

•

~$290 less than other sites

Dunescape Condos 103 - Palms Postcard

3 bedrooms•3 baths

•

~$150 less than other sites

Palmetto Beach Retreat - 405 Palm Blvd

3 bedrooms•2.5 baths

•

~$130 less than other sites

View all homes

Most popular amenities for vacation rentals in South Carolina

Basketball court (123)

More popular destinations in South Carolina

Other popular amenities & vacation types in South Carolina

Family vacation rentals in South Carolina

Large group vacation rentals in South Carolina

Pet-friendly vacation rentals in South Carolina

Beachfront vacation rentals in South Carolina

Hot tub vacation rentals in South Carolina

Lakefront vacation rentals in South Carolina

Private pool vacation rentals in South Carolina

Discover more of South Carolina

South Carolina balances Atlantic beauty with Lowcountry character. Hilton Head Island offers protected shoreline, lush fairways, and bike-friendly paths. Murrells Inlet delivers sweeping marsh vistas and unhurried sunset strolls along its boardwalk. Garden City Beach brings calm surf, a classic pier, and a nostalgic beach-town vibe.

Mild weather and abundant coastal nature make the Palmetto State ideal for family gatherings, long weekends, and extended stays. This is why Wander’s luxury vacation rentals in South Carolina are the perfect choice, whether you are traveling for work or leisure.

FAQs: Vacation Rentals in South Carolina

Why should I book a Wander in South Carolina over other vacation rentals?

Wander offers a level of consistency and quality you won’t find with most vacation rentals.

Every home in South Carolina delivers the quality of a luxury hotel, paired with the comfort and space of a private vacation home. You get hotel-grade amenities, meticulous cleaning, stunning views, and 24/7 concierge support in every stay. Why would you want to stay anywhere else?

Which are Wander’s most popular vacation rentals in South Carolina?

Some of our most popular vacation rentals in South Carolina include HH2611: 2611 High Hammock, IOP Life - 27 22nd Avenue, and Beach Please - 10 32nd Ave.. Guests love the quality of a luxury hotel, the comfort of a private vacation home, and the consistently exceptional experience Wander is known for. Explore the full collection to find the perfect home for your next stay.

How many different vacation rentals does Wander have available in South Carolina?

Wander offers 598 vacation rentals in South Carolina, each carefully designed and expertly operated. Browse the full collection to see what’s available for your trip.

What time is check-in and check-out at Wander’s vacation rentals in South Carolina?

You can check-in to Wander vacation rentals in South Carolina after 4.00pm and check-out before 10.00am.

Do Wander’s vacation rentals in South Carolina have WiFi access?

Yes. Every Wander home in South Carolina has ultra fast, reliable WiFi so you can stay connected throughout your stay.

What is Wander’s cancellation policy?

You can cancel your reservation within 24 hours of booking for a full refund.

For stays of less than 15 nights, you can cancel or reschedule up to 14 days before check-in for a full refund. For stays of 15 nights or longer, the cancellation window is 60 days.

For some homes, a 30-day deadline applies; this will be clearly shown before you book.