Luxury Vacation Rentals in South Carolina
Never book a bad vacation home again. Every Wander comes with hotel-grade amenities, inspiring views, pristine cleaning and 24/7 concierge service.
We found 72 vacation rentals – enter your dates for availability.
Hilton Head Island, South Carolina
Wander Hilton Head Waves
Next avail.
Dec 2 - Dec 4
621
Hilton Head Island, South Carolina
Wander Hilton Head Tides
Next avail.
Dec 2 - Dec 5
612
Hilton Head Island, South Carolina
Wander Hilton Head Oasis
Next avail.
Jan 2 - Jan 5
518
Hilton Head Island, South Carolina
Wander Hilton Head Paradise
Next avail.
Dec 2 - Dec 5
718
Hilton Head Island, South Carolina
Wander Hilton Head Cove
Next avail.
Dec 2 - Dec 4
618
Surfside Beach, South Carolina
Wander Surfside Beach Haven
Next avail.
Dec 2 - Dec 4
514
Eatonton, Georgia
Wander Oconee Shores
Next avail.
Dec 2 - Dec 6
614
4.8
Hilton Head Island, South Carolina
Wander Hilton Head Diamond
Next avail.
Dec 2 - Dec 4
511
Welcome to South Carolina
Find your coastal escape with Wander’s collection of luxury vacation rentals in South Carolina. From oceanfront retreats on Hilton Head Island to serene Lowcountry escapes in Murrells Inlet and family-friendly homes in Garden City Beach, every stay pairs privacy with polished design.
Expect hotel-grade standards across the board: spotless housekeeping, 24/7 concierge, ultra fast WiFi for work days, private pools and gyms for downtime, and chef-ready kitchens. Each home is thoughtfully outfitted with smart features and plush linens so you can unpack once and relax.
Destinations in South Carolina
Brevard, North Carolina
Wander Cedar Mountain
Next avail.
Dec 8 - Dec 10
410
4.7
Eatonton, Georgia
Wander Lake Oconee
Next avail.
Dec 2 - Dec 4
714
4.6
Greenville County, South Carolina
Wander Travelers Nest Cabin
Next avail.
Dec 9 - Dec 11
36
Six Mile, South Carolina
Wander Lake Keowee
Next avail.
Dec 2 - Dec 4
519
Cashiers, North Carolina
Wander Cashiers Brook
Next avail.
Dec 2 - Dec 4
512
Murrells Inlet, South Carolina
Wander Murrells Inlet Lagoon
Next avail.
Dec 7 - Dec 9
924
Murrells Inlet, South Carolina
Wander Murrells Inlet Tides
Next avail.
Dec 2 - Dec 4
414
Garden City Beach, South Carolina
Wander Murrells Inlet Horizon
Next avail.
Dec 2 - Dec 4
822
Hilton Head Island, South Carolina
Wander Hilton Head Paradise
Next avail.
Dec 2 - Dec 5
718
Hilton Head Island, South Carolina
Wander Hilton Head Dunes
Next avail.
Dec 2 - Dec 4
616
Hilton Head Island, South Carolina
Wander Hilton Head Bliss
Next avail.
Dec 11 - Dec 14
722
Hilton Head Island, South Carolina
Wander Hilton Head Diamond
Next avail.
Dec 2 - Dec 4
511
Hilton Head Island, South Carolina
Wander Hilton Head Crystal
Next avail.
Dec 4 - Dec 6
724
Garden City Beach, South Carolina
Wander Murrells Inlet Horizon
Next avail.
Dec 2 - Dec 4
822
Hilton Head Island, South Carolina
Wander Hilton Head Edge
Next avail.
Dec 2 - Dec 4
48
Murrells Inlet, South Carolina
Wander Murrells Inlet Dunes
Next avail.
Dec 2 - Dec 4
617
IT'S A VACATION HOME, BUT BETTER
The Wander difference
Wander is different because we combine the quality of a luxury hotel with the comfort of a private vacation home. Your best trip ever is just a few clicks away.
All homes in South Carolina
Hilton Head Island, South Carolina
Wander Hilton Head Waves
Next avail.
Dec 2 - Dec 4
621
Hilton Head Island, South Carolina
Wander Hilton Head Tides
Next avail.
Dec 2 - Dec 5
612
Hilton Head Island, South Carolina
Wander Hilton Head Oasis
Next avail.
Jan 2 - Jan 5
518
Hilton Head Island, South Carolina
Wander Hilton Head Paradise
Next avail.
Dec 2 - Dec 5
718
Hilton Head Island, South Carolina
Wander Hilton Head Cove
Next avail.
Dec 2 - Dec 4
618
Surfside Beach, South Carolina
Wander Surfside Beach Haven
Next avail.
Dec 2 - Dec 4
514
Eatonton, Georgia
Wander Oconee Shores
Next avail.
Dec 2 - Dec 6
614
4.8
Hilton Head Island, South Carolina
Wander Hilton Head Diamond
Next avail.
Dec 2 - Dec 4
511
Discover more of South Carolina
South Carolina balances Atlantic beauty with Lowcountry character. Hilton Head Island offers protected shoreline, lush fairways, and bike-friendly paths. Murrells Inlet delivers sweeping marsh vistas and unhurried sunset strolls along its boardwalk. Garden City Beach brings calm surf, a classic pier, and a nostalgic beach-town vibe.
Mild weather and abundant coastal nature make the Palmetto State ideal for family gatherings, long weekends, and extended stays. This is why Wander’s luxury vacation rentals in South Carolina are the perfect choice, whether you are traveling for work or leisure.