Luxury Vacation Rentals in South Carolina

Luxury Vacation Rentals in South Carolina

Never book a bad vacation home again. Every Wander comes with hotel-grade amenities, inspiring views, pristine cleaning and 24/7 concierge service.
We found 599 vacation rentals – enter your dates for availability.

Top-rated vacation rentals in South Carolina

Home in Isle of Palms property photo 1
Luxury

Home in Isle of Palms

7 bedrooms•8 baths
3,884 US dollars for 3 nights•
New

~$345 less than other sites

Condo in North Myrtle Beach property photo 1

Condo in North Myrtle Beach

3 bedrooms•3 baths
1,481 US dollars for 4 nights•
New

~$125 less than other sites

Condo in Myrtle Beach property photo 1

Condo in Myrtle Beach

3 bedrooms•3 baths
1,114 US dollars for 3 nights•
New

~$95 less than other sites

Condo in North Myrtle Beach property photo 1

Condo in North Myrtle Beach

2 bedrooms•2 baths
570 US dollars for 3 nights•

~$50 less than other sites

Home in Hilton Head Island property photo 1

Home in Hilton Head Island

4 bedrooms•4 baths
1,749 US dollars for 3 nights•
New

~$155 less than other sites

Home in Hilton Head Island property photo 1

Home in Hilton Head Island

5 bedrooms•6 baths
2,955 US dollars for 3 nights•
New

~$260 less than other sites

Home in Hilton Head Island property photo 1

Home in Hilton Head Island

5 bedrooms•5.5 baths
2,787 US dollars for 3 nights•
New

~$245 less than other sites

Property in Hilton Head Island property photo 1

Property in Hilton Head Island

4 bedrooms•4 baths
1,910 US dollars for 3 nights•
New

~$170 less than other sites

Welcome to South Carolina

Welcome to South Carolina

Find your coastal escape with Wander’s collection of luxury vacation rentals in South Carolina. From oceanfront retreats on Hilton Head Island to serene Lowcountry escapes in Murrells Inlet and family-friendly homes in Garden City Beach, every stay pairs privacy with polished design.
Expect hotel-grade standards across the board: spotless housekeeping, 24/7 concierge, ultra fast WiFi for work days, private pools and gyms for downtime, and chef-ready kitchens. Each home is thoughtfully outfitted with smart features and plush linens so you can unpack once and relax.

Destinations in South Carolina

Hilton Head Island
Hilton Head Island
Murrells Inlet
Murrells Inlet
Garden City Beach
Garden City Beach

Available soon in South Carolina

Condo in North Myrtle Beach property photo 1

Condo in North Myrtle Beach

2 bedrooms•2 baths
570 US dollars for 3 nights•

~$50 less than other sites

Home in Hilton Head Island property photo 1

Home in Hilton Head Island

4 bedrooms•4 baths
1,749 US dollars for 3 nights•
New

~$155 less than other sites

Home in Hilton Head Island property photo 1

Home in Hilton Head Island

5 bedrooms•6 baths
2,955 US dollars for 3 nights•
New

~$260 less than other sites

Home in Hilton Head Island property photo 1

Home in Hilton Head Island

5 bedrooms•5.5 baths
2,787 US dollars for 3 nights•
New

~$245 less than other sites

Home in Seabrook Island property photo 1

Home in Seabrook Island

5 bedrooms•3.5 baths
2,722 US dollars for 3 nights•
New

~$240 less than other sites

Home in Hilton Head Island property photo 1

Home in Hilton Head Island

6 bedrooms•6.5 baths
5,934 US dollars for 3 nights•
New

~$525 less than other sites

Home in Kiawah Island property photo 1

Home in Kiawah Island

4 bedrooms•3.5 baths
3,028 US dollars for 3 nights•
New

~$265 less than other sites

Home in Isle Of Palms property photo 1

Home in Isle Of Palms

6 bedrooms•6 baths
3,212 US dollars for 3 nights•
New

~$280 less than other sites

Featured vacation rentals in South Carolina

Home in Isle of Palms property photo 1
Luxury

Home in Isle of Palms

5 bedrooms•5.5 baths
2,959 US dollars for 3 nights•

~$260 less than other sites

Home in Isle Of Palms property photo 1

Home in Isle Of Palms

6 bedrooms•5.5 baths
3,798 US dollars for 3 nights•
New

~$335 less than other sites

Home in Kiawah Island property photo 1
Luxury

Home in Kiawah Island

5 bedrooms•4.5 baths
4,297 US dollars for 3 nights•
New

~$380 less than other sites

Home in Kiawah Island property photo 1

Home in Kiawah Island

6 bedrooms•6.5 baths
3,990 US dollars for 3 nights•
New

~$355 less than other sites

Home in Isle of Palms property photo 1

Home in Isle of Palms

8 bedrooms•7 baths
4,044 US dollars for 3 nights•

~$360 less than other sites

Home in Isle of Palms property photo 1

Home in Isle of Palms

6 bedrooms•6 baths
3,621 US dollars for 3 nights•

~$315 less than other sites

Home in Hilton Head Island property photo 1
Luxury

Home in Hilton Head Island

8 bedrooms•7.5 baths
5,986 US dollars for 3 nights•
New

~$530 less than other sites

Home in Isle of Palms property photo 1
Luxury

Home in Isle of Palms

6 bedrooms•3.5 baths
5,060 US dollars for 3 nights•

~$450 less than other sites

Highlights in South Carolina

Discover a state where historic cities, sun-drenched coastlines, and classic Southern charm create an unforgettable and diverse travel experience.
Charleston's Historic District
Myrtle Beach Boardwalk and Promenade
Hilton Head Island
Fort Sumter National Monument
Congaree National Park
South Carolina State House
Caesars Head State Park
Magnolia Plantation and Gardens

IT'S A VACATION HOME, BUT BETTER

The Wander difference

Wander is different because we combine the quality of a luxury hotel with the comfort of a private vacation home. Your best trip ever is just a few clicks away.

Only the best homes

We’ll never not look like the pictures. Every Wander is beautiful and expertly operated, so you can leave any stress at the door.

Hotel-grade amenities

We’ll never leave you with nothing to do. From ultra fast WiFi to gyms and pools, our homes make it easy to blend work and play.

24/7 concierge service

We’ll never leave you hanging. Our chat-based Concierge is always available to help – from trip questions to special requests.

Inspiring and stunning views

We’ll never leave you uninspired. Every Wander has stunning views to refresh and inspire your soul. Adventure awaits.

Meticulous cleaning

We’ll never have you check in to a dirty house. Our cleaning teams are meticulous, and there are no chores at checkout.

Safety and security

We’ll never pass you off to a stranger. Every Wander location meets our industry-leading safety standards to give you peace of mind.

All homes in South Carolina

Home in Isle of Palms property photo 1
Luxury

Home in Isle of Palms

7 bedrooms•8 baths
3,884 US dollars for 3 nights•
New

~$345 less than other sites

Condo in North Myrtle Beach property photo 1

Condo in North Myrtle Beach

3 bedrooms•3 baths
1,481 US dollars for 4 nights•
New

~$125 less than other sites

Condo in Myrtle Beach property photo 1

Condo in Myrtle Beach

3 bedrooms•3 baths
1,114 US dollars for 3 nights•
New

~$95 less than other sites

Condo in North Myrtle Beach property photo 1

Condo in North Myrtle Beach

2 bedrooms•2 baths
570 US dollars for 3 nights•

~$50 less than other sites

Home in Hilton Head Island property photo 1

Home in Hilton Head Island

4 bedrooms•4 baths
1,749 US dollars for 3 nights•
New

~$155 less than other sites

Home in Hilton Head Island property photo 1

Home in Hilton Head Island

5 bedrooms•6 baths
2,955 US dollars for 3 nights•
New

~$260 less than other sites

Home in Hilton Head Island property photo 1

Home in Hilton Head Island

5 bedrooms•5.5 baths
2,787 US dollars for 3 nights•
New

~$245 less than other sites

Property in Hilton Head Island property photo 1

Property in Hilton Head Island

4 bedrooms•4 baths
1,910 US dollars for 3 nights•
New

~$170 less than other sites

View all homes

Most popular amenities for vacation rentals in South Carolina

Outdoor pool (356)
Private chef (30)
Jacuzzi (142)
Heated pool (129)
Hot tub (142)
Ocean view (100)
Ev charger (33)
Basketball court (123)
Indoor pool (18)
Waterfront (121)
Beachfront (24)
Beach access (237)
Outdoor shower (51)
Tennis court (29)
Movie theater (1)
Bicycle (40)

More popular destinations in South Carolina

North Carolina
Georgia
Virginia
Tennessee
Maryland
Florida
Ohio
Indiana

Other popular amenities & vacation types in South Carolina

Family vacation rentals in South Carolina
Large group vacation rentals in South Carolina
Pet-friendly vacation rentals in South Carolina
Beachfront vacation rentals in South Carolina
Hot tub vacation rentals in South Carolina
Lakefront vacation rentals in South Carolina
Private pool vacation rentals in South Carolina
Discover more of South Carolina

Discover more of South Carolina

South Carolina balances Atlantic beauty with Lowcountry character. Hilton Head Island offers protected shoreline, lush fairways, and bike-friendly paths. Murrells Inlet delivers sweeping marsh vistas and unhurried sunset strolls along its boardwalk. Garden City Beach brings calm surf, a classic pier, and a nostalgic beach-town vibe.
Mild weather and abundant coastal nature make the Palmetto State ideal for family gatherings, long weekends, and extended stays. This is why Wander’s luxury vacation rentals in South Carolina are the perfect choice, whether you are traveling for work or leisure.

FAQs: Vacation Rentals in South Carolina

Why should I book a Wander in South Carolina over other vacation rentals?

Wander offers a level of consistency and quality you won’t find with most vacation rentals.
Every home in South Carolina delivers the quality of a luxury hotel, paired with the comfort and space of a private vacation home. You get hotel-grade amenities, meticulous cleaning, stunning views, and 24/7 concierge support in every stay. Why would you want to stay anywhere else?

Which are Wander’s most popular vacation rentals in South Carolina?

Some of our most popular vacation rentals in South Carolina include The Rosewood Retreat - 2605 Palm Blvd., Luxury 3BR Oceanfront Penthouse w/ Lazy River, and Anderson Ocean Club 3BR - Sleeps 8 w/ Pools & Spa. Guests love the quality of a luxury hotel, the comfort of a private vacation home, and the consistently exceptional experience Wander is known for. Explore the full collection to find the perfect home for your next stay.

How many different vacation rentals does Wander have available in South Carolina?

Wander offers 599 vacation rentals in South Carolina, each carefully designed and expertly operated. Browse the full collection to see what’s available for your trip.

What time is check-in and check-out at Wander’s vacation rentals in South Carolina?

You can check-in to Wander vacation rentals in South Carolina after 4.00pm and check-out before 10.00am.

Do Wander’s vacation rentals in South Carolina have WiFi access?

Yes. Every Wander home in South Carolina has ultra fast, reliable WiFi so you can stay connected throughout your stay.

What is Wander’s cancellation policy?

You can cancel your reservation within 24 hours of booking for a full refund.
For stays of less than 15 nights, you can cancel or reschedule up to 14 days before check-in for a full refund. For stays of 15 nights or longer, the cancellation window is 60 days.
For some homes, a 30-day deadline applies; this will be clearly shown before you book.