Luxury Vacation Rentals in Isle of Palms

Never book a bad vacation home again. Every Wander comes with hotel-grade amenities, inspiring views, pristine cleaning and 24/7 concierge service.

We found 84 vacation rentals – enter your dates for availability.

Top-rated vacation rentals in Isle of Palms

Oceanside Villas 211C - Villa Solea - 1400 Ocean Blvd Unit 211C

2 bedrooms•2 baths

•

~$70 less than other sites

Sea Cabins 230B - Seaside Sanctuary - Luxury Oceanfront Condo

1 bedroom•1 bath

•

~$70 less than other sites

Luxury

Palms Paradise - Home with Private Pool - 3 29th Ave

5 bedrooms•5.5 baths

•

~$280 less than other sites

Oceanside Villas 111C - Deja Blue - 1400 Ocean Blvd Unit 111C

2 bedrooms•2 baths

•

New

~$80 less than other sites

Luxury

Beach Please - 10 32nd Ave

5 bedrooms•4.5 baths

•

~$255 less than other sites

CM3302: 3302 Cameron Blvd

6 bedrooms•5.5 baths

•

New

~$365 less than other sites

AV8-53: 8 53rd Avenue

5 bedrooms•3.5 baths

•

New

~$210 less than other sites

AV19-21: 19 21st Avenue

6 bedrooms•5 baths

•

New

~$345 less than other sites

Welcome to Isle of Palms

Set your sights on the Atlantic with Wander’s luxury vacation rentals in Isle of Palms. Our collection includes breezy oceanfront homes, elevated coastal cottages, and quiet marsh-view escapes, all designed for effortless indoor and outdoor flow and restorative privacy.

Every home delivers hotel-grade polish with ultra fast WiFi, dedicated workspaces, spa-level linens, pristine cleaning, sparkling kitchens ready for a chef, and 24/7 concierge. Many feature private pools, sun decks, and panoramic terraces, so downtime feels intentional.

Choose a beachfront haven for a milestone gathering or a tranquil hideaway for deep focus. With Wander you get the consistency of a luxury hotel and the comfort of a private home.

Destinations near Isle of Palms

Available soon in Isle of Palms

Oceanside Villas 211C - Villa Solea - 1400 Ocean Blvd Unit 211C

2 bedrooms•2 baths

•

~$70 less than other sites

Sea Cabins 230B - Seaside Sanctuary - Luxury Oceanfront Condo

1 bedroom•1 bath

•

~$70 less than other sites

Oceanside Villas 111C - Deja Blue - 1400 Ocean Blvd Unit 111C

2 bedrooms•2 baths

•

New

~$80 less than other sites

Luxury

Beach Please - 10 32nd Ave

5 bedrooms•4.5 baths

•

~$255 less than other sites

CM3302: 3302 Cameron Blvd

6 bedrooms•5.5 baths

•

New

~$365 less than other sites

AV19-21: 19 21st Avenue

6 bedrooms•5 baths

•

New

~$345 less than other sites

AV15-42: 15 42nd Avenue

6 bedrooms•6 baths

•

New

~$280 less than other sites

AV4-22: 4 22nd Avenue

5 bedrooms•3.5 baths

•

New

~$230 less than other sites

Featured vacation rentals in Isle of Palms

Twin Palms - Home with Pool

7 bedrooms•5 baths

•

~$360 less than other sites

CM3008: 3008 Cameron Blvd

7 bedrooms•7 baths

•

New

~$295 less than other sites

Beach Retreat - 3407 Palm Blvd

9 bedrooms•9 baths

•

~$415 less than other sites

PALM2807: 2807 Palm Blvd

7 bedrooms•7.5 baths

•

New

~$370 less than other sites

PALM3907: 3907 Palm Blvd

8 bedrooms•8.5 baths

•

New

~$755 less than other sites

HN2307: 2307 Hartnett Blvd

5 bedrooms•4.5 baths

•

New

~$330 less than other sites

Luxury

Shore Thing - 4001 Palm Blvd

6 bedrooms•6.5 baths

•

New

~$600 less than other sites

Luxury

Cameron By The Sea - 3203 Cameron Blvd

6 bedrooms•7 baths

•

~$485 less than other sites

Highlights in Isle of Palms

Discover a serene coastal escape with pristine beaches, championship golf, and abundant water activities on this charming South Carolina barrier island.

Isle of Palms County Park

Isle of Palms Marina

Wild Dunes Resort

Front Beach on Isle of Palms

Breach Inlet

Capers Island Heritage Preserve

Sullivan's Island Lighthouse

IT'S A VACATION HOME, BUT BETTER

The Wander difference

Wander is different because we combine the quality of a luxury hotel with the comfort of a private vacation home. Your best trip ever is just a few clicks away.

Only the best homes

We’ll never not look like the pictures. Every Wander is beautiful and expertly operated, so you can leave any stress at the door.

Hotel-grade amenities

We’ll never leave you with nothing to do. From ultra fast WiFi to gyms and pools, our homes make it easy to blend work and play.

24/7 concierge service

We’ll never leave you hanging. Our chat-based Concierge is always available to help – from trip questions to special requests.

Inspiring and stunning views

We’ll never leave you uninspired. Every Wander has stunning views to refresh and inspire your soul. Adventure awaits.

Meticulous cleaning

We’ll never have you check in to a dirty house. Our cleaning teams are meticulous, and there are no chores at checkout.

Safety and security

We’ll never pass you off to a stranger. Every Wander location meets our industry-leading safety standards to give you peace of mind.

All homes in Isle of Palms

Oceanside Villas 211C - Villa Solea - 1400 Ocean Blvd Unit 211C

2 bedrooms•2 baths

•

~$70 less than other sites

Sea Cabins 230B - Seaside Sanctuary - Luxury Oceanfront Condo

1 bedroom•1 bath

•

~$70 less than other sites

Luxury

Palms Paradise - Home with Private Pool - 3 29th Ave

5 bedrooms•5.5 baths

•

~$280 less than other sites

Oceanside Villas 111C - Deja Blue - 1400 Ocean Blvd Unit 111C

2 bedrooms•2 baths

•

New

~$80 less than other sites

Luxury

Beach Please - 10 32nd Ave

5 bedrooms•4.5 baths

•

~$255 less than other sites

CM3302: 3302 Cameron Blvd

6 bedrooms•5.5 baths

•

New

~$365 less than other sites

AV8-53: 8 53rd Avenue

5 bedrooms•3.5 baths

•

New

~$210 less than other sites

AV19-21: 19 21st Avenue

6 bedrooms•5 baths

•

New

~$345 less than other sites

View all homes

Most popular amenities for vacation rentals in Isle of Palms

Other popular amenities & vacation types in Isle of Palms

Beachfront vacation rentals in Isle of Palms

Pet-friendly vacation rentals in Isle of Palms

Private pool vacation rentals in Isle of Palms

Large group vacation rentals in Isle of Palms

Family vacation rentals in Isle of Palms

Hot tub vacation rentals in Isle of Palms

Discover more of Isle of Palms

Isle of Palms stretches along six miles of soft sand with gentle surf, sweeping dunes, and glowing sunrises over the Atlantic. Beyond the beach, tidal creeks and the Intracoastal Waterway frame a serene landscape for dolphin sightings and painted sunsets, while breezes drift through sea oats and live oaks.

Pair the island’s laid-back rhythm with the cultural richness of nearby Charleston just across the bridge, then return to a world where salt air and starry skies set the tone. This effortless blend of natural beauty and easy access is why Wander’s luxury vacation rentals in Isle of Palms are the perfect choice, whether you are traveling for work or leisure.

FAQs: Vacation Rentals in Isle of Palms

Why should I book a Wander in Isle of Palms over other vacation rentals?

Wander offers a level of consistency and quality you won’t find with most vacation rentals.

Every home in Isle of Palms delivers the quality of a luxury hotel, paired with the comfort and space of a private vacation home. You get hotel-grade amenities, meticulous cleaning, stunning views, and 24/7 concierge support in every stay. Why would you want to stay anywhere else?

Which are Wander’s most popular vacation rentals in Isle of Palms?

Some of our most popular vacation rentals in Isle of Palms include Oceanside Villas 211C - Villa Solea - 1400 Ocean Blvd Unit 211C, Sea Cabins 230B - Seaside Sanctuary - Luxury Oceanfront Condo, and Palms Paradise - 5 BR Home with Private Pool - 3 29th Ave. Guests love the quality of a luxury hotel, the comfort of a private vacation home, and the consistently exceptional experience Wander is known for. Explore the full collection to find the perfect home for your next stay.

How many different vacation rentals does Wander have available in Isle of Palms?

Wander offers 84 vacation rentals in Isle of Palms, each carefully designed and expertly operated. Browse the full collection to see what’s available for your trip.

What time is check-in and check-out at Wander’s vacation rentals in Isle of Palms?

You can check-in to Wander vacation rentals in Isle of Palms after 4.00pm and check-out before 10.00am.

Do Wander’s vacation rentals in Isle of Palms have WiFi access?

Yes. Every Wander home in Isle of Palms has ultra fast, reliable WiFi so you can stay connected throughout your stay.

What is Wander’s cancellation policy?

You can cancel your reservation within 24 hours of booking for a full refund.

For stays of less than 15 nights, you can cancel or reschedule up to 14 days before check-in for a full refund. For stays of 15 nights or longer, the cancellation window is 60 days.

For some homes, a 30-day deadline applies; this will be clearly shown before you book.